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Weekly Dose: doxycycline treats a host of human plagues

 

Doxycycline is an antibiotic drug that kills a wide, weird and wonderful range of bugs that are often troublesome to treat with other antibiotics. These embrace bacteria and parasites that take up residence inside our cells (called "intracellular organisms"), making them hard for most antibiotics to reach.

 

 

Unlike many other antibiotics, doxycycline penetrates deep into our tissues and ends up inside our cells, the place it can kill these bugs. Examples of intracellular organisms prone to doxycycline include quite a few "zoonotic infections" (infections that are spread from animals to humans), chlamydia, legionella (the cause of legionnaire’s illness) and malaria.

 

 

Other vulnerable microorganisms embrace "spirochaetes" (that may cause syphilis and Lyme disease) and the bacteria that cause acne, anthrax and cholera.

 

 

Doxycycline interferes with a microorganism’s ability to fabricate proteins – the "building blocks" of life. Protein manufacture occurs in a part of the cell called the "ribosome" and is fundamental to any organism’s survival.

 

 

The reason doxycycline kills bacteria and parasites, however not our own cells, is that ours have a special type of ribosome to these less complicated organisms.

 

 

Uses

 

Because doxycycline kills a wide range of bacteria that may infect the respiratory system, it is commonly prescribed for pneumonia and bronchitis. It is usually widely used for treating acne and infections of the urinary and genital systems.

 

 

It is usually taken orally as tablets or capsules but can also very sometimes be given as an intravenous injection.

 

 

Doxycycline continues to exert its effects for some time after being taken. This means it can be used not only as therapy, but in addition for prevention or "prophylaxis".

 

 

Its most widespread use as prophylaxis is for tourists and other travellers (corresponding to military personnel) going to tropical countries where it is used to protect primarily against malaria. It may additionally provide additional protection from widespread bacterial causes of diarrhoea.

 

 

To be effective in preventing infection, it must be taken once a day in the course of the time the person is at risk. Doxycycline can also be active in opposition to a number of bacteria that could presumably be used as agents of "germ" warfare. This included, most notably, anthrax. So it could possibly be used as prophylaxis in military or other populations considered at risk of bio-warfare or following release of anthrax into the atmosphere by terrorists.

 

 

Development

 

The development of doxycycline adopted the momentous discovery of penicillin, a natural compound produced by a sure type of mould.

 

 

This lead many pharmaceutical corporations to research the microbe-killing properties of a giant number of different natural products, resembling these produced by different microorganisms and plants, a process termed "bio-discovery".

 

 

This unearthed natural compounds with anti-microbial activity and additional artificial modification improved these natural compounds.

 

 

Resistance

 

Like all antibiotics, doxycycline is inclined to bugs that develop resistance. There may be proof this has already occurred in settings the place the drug is widely used, such as treatment of acne.

 

 

This means its use could also be curtailed or overtaken by alternative medicine for some conditions, now or within the future.

 

 

Side effects and reactions

 

Essentially the most commonly reported side effect is irritation of the oesophagus (food pipe), inflicting heartburn. This might be quite unpleasant however is somewhat preventable by taking the remedy with loads of water, while standing and well earlier than going to bed.

 

 

"Photosensitivity" (heightened sensitivity to sunlight resulting in being easily sunburnt) can also be widespread ( in as much as 20% of people taking it). This is particularly problematic for travellers using it as malaria prophylaxis in tropical countries.

 

 

Doxycycline shouldn't be utilized in children or in pregnant ladies where it may end up in permanent brown staining of enamel and have other effects on foetal bone development.

 

 

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Website: https://medssafety.com/doxycycline-ruined-my-life-part-2/

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